I strongly suspect liver overload / inability to detoxify both testosterone and estrogen may be contributing to my issues. I was researching about hormonal acne and about androgen levels and your post is very informative. I have been on the pill for two years. Hi Alison, Are there any alternative solutions which can help me to lower my DHEA-S level ? I think every woman should read it! My main concern now is mood swings crying mad and sugar dropping exatly 2.5 hours after I eat. My Serum ferratin was originally 60, its now 70 and the doctor wants me to increase to 100 for optimal hair regrowth. I can’t tell you how much I appreciate it as I feel incredibly desperate and hopeless about this situation. Will supplementing estrogen help? I don’t recommend saliva testing, except maybe to measure cortisol. Hi Kellie, Thank you so much for this information its the best I have read! Hi Mimi, Your hypoglycemia symptom suggests a problem with adrenal glands or HPA axis. Please help not sure what is causing me so many issues. Please answear. I was diagnosed with PCOS when I was 17, and straightly prescribed birth control pills. I had a saliva hormone test done. – overactive thyroid I’m anxious about it. Just general medicine and tablets, sadly. Irritability. NOTHING any of them ever did or prescribed or recommended worked. Check the full list of possible causes and conditions now! Now according to blood test it’s 80. I was either pregnant or breastfeeding for 3 years, and had very clear skin. I wonder why it’s such a common side effect. Losing your hair either way is devastating. Its thinning on top , especially where my part is, and around one of my temples, I have very thick hair so this is quite noticable ( to me anyway)! I have no celiac. Because you’re not having periods, you are essentially in your follicular phase continuously. PRL 254.7 MIU/L (now 18.4ng/ml) When I read your book, it was very helpful but I never “perfectly” fit to any of those categories since I have regular periods. 1,3,6 These steroids (progesterone and 17-hydroxyprogesterone) are shunted into the adrenal androgen pathway that leads to increased concentrations of dehydroepiandrosterone and androstenedione. Could it be related? Sorry for the rambling essay! I feel this site can help my life. I discuss the different types of PCOS in my book Period Repair Manual. In any case, I am actively managing my stress, eating a very healthy diet per your recommendations, and supplementing with a quality multivitamin, vitamin D, vitamin C, magnesium, zinc, probiotic, fish oil, spearmint tea / green tea and am considering adding red reishi and ashwagandha or rhiodola to the mix. I stopped and started the pill earlier in the year and experienced hair loss around that time too. Now I’ve been bleeding for 21 days and my face is starting to break out again, not as bad as in the past, and I’m feeling low. Just the appearance of the miniaturized follicles. Unfortunately, it’s one of the third generation progestins (like drospirenone) that has a frighteningly high blood clot risk. Causes of high SHBG include: Also, are your menstrual cycles regular and do you have excess body hair in a male pattern ? I do very appreciate your help! Please help. [ncbi.nlm.nih.gov], They are feminizing tumors with direct secretion of estrogens and steroid precursors, like androstenedione. However, I would also test for fasting insulin, to determine if there is insulin resistance (if there is, then I would lean more towards treatment of classical PCOS, or ovarian androgens). Your testosterone is high. A month before coming off the pill, when you stop the pill, or at another stage? That’s it. Total Testosterone: 50 (2-45 ng/dl) Would I be correct in thinking if I take pregnenolone when coming off pill it will help create the hormones I am lacking – I am guessing I am low in estrogen and have too much testosterone/androgens. I don’t wear face makeup of any kind (eyeliner and mascara only for me). Almost the same month i stopped taking the pills my period was going strange, i had spottings 1 week before expekted time and I started to get dark hair on my chin. Should I take the medication n hope for the best? Maybe I should try spearmint and beta-sitosterol. Most mild-to-moderate elevations in androstenedione are idiopathic. Do you have any insight as to what could have caused temporary elevated levels of total testosterone but normal free testosterone? Tip: Menopause is another time of relative androgen excess or “testosterone dominance.”. I currently have the Nexplanon implant (have had it since March this year) and had been getting on fine. I never had a great feeling about taking a drug originally created for one thing to solve another thing. Yes, I have had a period consistently every month since stopping the pill little over a year ago. I have now the diagnose PCOS after beeing on the pill during 13 years. Started progesterone cream daily. Found insideReading this book will lead to a better understanding of management of both sexes, and the understanding of infertility that will hopefully reduce the effort, the time, the psychological, and the financial burden of the infertile couple and ... Unfortunately this time my dream-s went back up into the high 400’s and my vitamin d dipped down a little but I was still in the low normal range. See if your doctor feels it’s suitable to test “iron studies” and serum zinc, if she hasn’t already. Inositol 1.0g I’d love to hear more about your story for a piece I’m writing on it. DHEAS were on the lower end, and Androsterone was still soaringly high (this has always been the metabolite giving me issues it seems….) After seeing my 3rd Dr, i finally got one to agree with me. [ncbi.nlm.nih.gov], Although the levels of 17-hydroxyprogesterone and androstenedione are greatly elevated in classic 21-hydroxylase deficiency, a more extensive panel is recommended so that And if you do have CAH, then yes, that will be the answer (and treatment will be the solution). While searching for answers, I came across your post on Spiro and it just opened my world to a different approaches on this whole hair loss journey. I am 26 now and know better! I get the sugar cravings only when I’m about to start . Liver disease or cirrhosis. Please see my 4 Types of PCOS post. This month, however seems different. I am not overweight (my BMI is 18 and has always been around 18/19), don’t have much acne (I had breakouts for three months after stopping the pill but my skin has since calmed down a lot), and have no problems with hirsutism. Please suggest me which one to look into. Values are changing, because when i stopped eating Diane35 four years ago(2015) i had low TSH, high LH, high testosterone.Then just four months later TSH normal. I don’t even have elevated testosterone but I have high DHEAS and that’s an androgen too. Mine are irregular. Sorry I never emailed directly. Men with raised androstenedione may be asymptomatic, but through peripheral conversion of androgens to oestrogens can occasionally experience mild symptoms of oestrogen excess. [scielo.br], Plasma estradiol (E2, 142pmol/l) was minimally elevated, but testosterone (T, 8.2) and androstenedione (A, 10.4nmol/l) were high. There is also the Daysy contraceptive device. Iron (88 (range 27-159) I had high prolactin, high DHEA-S, Low progesterone, Low estrogen…they found a pituitary adenoma so now my prolactin is very low thanks to medication. I’m in my 20s. My question- how do I lower Androstenedione specifically since this appears to be the only hormone problem I have at this time. I’ve been struggling with cystic acne, folliculitis and hair loss for a long time. What was your fasting and 1 hour reading? According to him these pills and drops will help balance my hormones and i should eventually have regular periods. Periods pretty much normal and painless for the past 2+ years since quitting pill…. I experienced TE when I came off Yasmin in 2014 and I was in recovery. There are other solutions for acne, which I discuss in my post Insight Into Acne. I’m desperate. Have you read my book Period Repair Manual? Stressful 5 years, although I meditate. Further as you say most of your other hormone levels are normal. that was almost 3 yrs ago. Can you recommend treatment for high DHT levels? Hemoglobin A1c: 4.9 I appreciate your guidance and support for us girls. It worked quickly and well. But I don’t know which Androgen is high in my case. I recently removed gluten and dairy from my diet but haven’t been able to cut out chocolate yet. How does one know which type of PCOS they have? No women in my family ever lost their hair in their 30s. I too think i have adrenal androgen excess…. In short, both Myo-Inositol and D-Chiro-Inositol are helpful. OBGYN or Endocrinologist? Most mild-to-moderate elevations in DHEAS levels are idiopathic. Found insideOutlines the basics of congenital adrenal hyperplasia and its interrelation with hormones and bodily functions Presents the known cognitive and emotional aspects of the disease Reviews multidisciplinary management as well as post-treatment ... Androgens from other parts of the body can also cause male characteristics to develop in women. Do you have any experience with (or opinion on) the supplement T-Clear (Metagenics brand) to lower testosterone? So…. My case is a little special (I wrote you a quite long email to explain every analysis I did during the last 4 years, I also saw many specialists who couldn’t tell me what I suffer from and what to do..) The best way to improve things is to start to ovulate regularly so you can make estrogen and progesterone. Yes, I have also seen patients whose main issue was elevated SHBG. Does it even help adrenal androgens? Dr. Briden, I’ve seen references that DIM can block T -> DHT conversion, which helps androgenic symptoms, but that it can also lead to higher circulating testosterone levels by inhibiting conversion of testosterone to estrogen. Only since I have come off the combined pill after so long , am I getting all these symptoms . Its seriously is enough to make any desperate twenty something year old crazy. Could the decrease in the Lexapro cause an increase in DHEA-s? In other words; estrogen is made from testosterone through aromatase. My mom and sister of similar size have perfectly normal cycles, not me! I’ve done a thyroid test but no problem. I know licorice is an androgen blocker but can it lower DHEA-S paradoxically somehow? This text contains the proceedings of a 2001 workshop on the topic. I wouldn’t expect Rhodiola to raise androgen levels. I believe androsterone is a metabolic breakdown product of a few different androgens, but mostly adrenal androgens. I had heard that Saw Palmetto is a possible treatment but would like your opinion. You’ll know from reading my blog and my book, that I almost never think the Pill is the right solution for PCOS or any other period problem. Any ideas? I starved myself to lose weight and was on yo-yo diets when I was 14 and 15.In just couple of months I shed alot of hair, and a year later I started to grow thick hair on my cheeks, chin, nipples, belly and my chest. I went to the endocrinologist because of elevated prolactin (I went to the lab a couple of times before that, and also discovered high LH – that’s why I suspected I’ve got PCOS)… I had been taking peony&licorice for about two months, when I went to the endocrinologist… So, the results showed normal prolactin levels, also testosterone, DHEA, androstendione… SHBG was elevated (151) As I read, in case of PCOS SHBG levels should be lower than normal not opposite?
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